Is Keto Safe? Short- And Long-Term Risks Of The Keto Diet

The Merriam-Webster dictionary defines “safe” this way: “secure from threat of danger, harm, or loss.”

That covers an awful lot of ground. That’s why we can’t simply say “yes, the keto diet is safe – nothing to see here.”

Here’s what can be said, though, about the keto diet and “danger, risk and loss”:

However, not enough research has been done to determine whether a ketogenic eating plan can harm your body over the long run. It has been established that keto can be dangerous to people with very specific health problems. And you may experience some temporary discomfort or minor physical symptoms while adjusting to the diet.

If a doctor or registered dietitian suggests the keto diet, you should be in the clear. But if you’re ready to try the diet on your own, there’s more you need to know first.

Read on.

Defining Ketosis

Understanding why keto works – and why it’s safe for most people – requires a brief explanation.

The carbohydrates in your diet are normally used by the body to create energy. Carbs are converted into glucose (also called blood sugar), and used as fuel to power the body’s metabolism.

That makes it difficult to lose weight, though, because the process leaves stored body fat untouched. Something has to change before the body is forced to burn its stored fat for energy.

The keto diet causes that change.

You probably know that keto is a low-carb, high-fat diet. There’s no immediate risk there, because the fat you eat on the keto diet (along with moderate amounts of protein) provides the calories the body needs. However, the diet provides very few carbohydrates for the body to convert to energy.

In “desperation,” the body finds an alternate energy source: ketones. 

Ketones (scientific name: ketone bodies) are created when stored fat and fatty acids are broken down in the liver in a process known as ketogenesis. The ketones are then sent to the brain as fuel; thankfully, the body can run just fine on ketones instead of glucose. (1)

The metabolic state in which the body uses ketones for energy is known as ketosis. The goal of the keto diet is to put the body into ketosis and keep it there, because that’s when stored fat is continuously burned – resulting in weight loss.

How We Know Ketosis is Safe

This is the clearest indication that ketosis is a safe metabolic state: doctors have been using a low-carb, high fat diet to put childhood epilepsy patients into ketosis for 100 years. Until the development of more effective medications, a diet similar to keto was used for patients who didn’t respond to other treatments. (2) More recently, a ketogenic diet has also been put into doctors’ toolboxes for their adult patients with epilepsy. (3)

Almost all of the research into keto eating plans shows that staying in ketosis for several months is safe, and an effective weight loss tool for most patients (4)(5) (6). It’s even been proven safe for soldiers in military training. (7)

There have been a few studies showing that ketosis and the ketogenic diet are safe for periods of time as long as six months. (8) Academic research into the effects of keto over longer time frames is limited and somewhat contradictory. (9)

However, that doesn’t mean that a short-term keto diet is completely without risk – particularly for those following the diet without the help of a dietitian.

Possible Side Effects of Keto

A keto diet can lead to both expected and unexpected medical complications. In most cases they’re not serious, and can be avoided or minimized.

The Keto Flu

The most predictable effect of a ketogenic diet has earned the nickname “the keto flu.” It’s caused when the body switches its energy source from glucose to ketones and is entering ketosis.

That big change in metabolic fuel often leads to symptoms very similar to the actual flu: tiredness and exhaustion, headache, cramps, nausea and vomiting. Frequent urination is also common, as the body loses water weight and tries to excrete excess ketones.

The keto flu generally lasts only a few days, from the start of a keto diet until the body reaches full ketosis. It’s possible to shorten that time period with increased hydration and by eating foods rich in nutrients like potassium, sodium and magnesium. Supplements can be a faster and easier way to replace those lost nutrients, as long as they’re not in electrolyte drinks which contain sugar.

The duration of the keto flu can also be lessened with sufficient rest and sleep, and avoiding serious exercise for a few days.

When the flu eases, that’s good news for two reasons. Not only do you feel better, but it means your body is in ketosis and you’re ready for serious weight loss.

Unexpected Complications

Those who rigorously follow the keto diet, the Atkins diet or other low-carb diets eliminate many important sources of nutrients, such as legumes, fruits and whole grains. That can create deficiencies in important micronutrients like magnesium, selenium, citrate, vitamins A, B7 and B9, D, and E. (10)

Some elements of the keto diet can also cause other problems. For example, eating a lot of high-fat animal foods can cause urine and blood to become too acidic. A drastic reduction in carbohydrates can limit dietary fiber. 

Some of the medical issues which can develop due to those issues include kidney stones (11), osteoporosis and bone loss (12), flare-ups in patients with gout (13), digestive problems and constipation (14). Most keto dieters don’t experience any of them, but they are certainly possible.

Consulting a nutritionist or dietitian, who can help you avoid those deficiencies and issues, is always a good idea before making any major dietary changes. At the very least, some vitamin and mineral supplements should be considered.

One other risk of a keto diet isn’t literally a health risk, but it’s common: when people go back to their “normal” way of eating, weight gain is typical. In fact, when some end their keto diet they regain most or all of their lost weight. A maintenance diet of some sort is usually required to keep the weight off, whether it involves staying with keto-friendly meal plans or switching to a healthy, balanced diet.

The side effects of keto are either transient or largely preventable, so keto is safe for nearly everyone. Some serious medical conditions and illnesses don’t play well with keto, however.

Who Should Not Follow a Keto Diet

Ketosis changes how many of the body’s systems function. If those systems aren’t healthy to begin with, a keto diet could be problematic or even dangerous.

Experts also caution against a keto diet for those with eating disorders, and women who are pregnant or nursing.

Long-Term Keto Diets and Possible Risks

Our discussion on the safety of the keto diet has so far centered on its use for weight loss over a period of several months. And evidence clearly shows that it is safe for most people over the short term.

The majority of medical professionals recommend three months as the outside limit for a keto diet. Some say do say, though, that cyclical keto program (for example, three months on and one month off), can safely be followed for longer periods.

The reason that keto is not recommended for permanent dieting and maintenance is that the long-term results and health risks of a ketogenic diet are still up for debate.

Some concerns center around the possible nutritional deficits mentioned earlier. The longer people remain on keto, the greater the chance that they could suffer complications involving dehydration, electrolyte imbalances and even hypoglycemia. (17)

There are also more serious concerns. An extensive survey of 25,000 Europeans presented in late 2019 reviewed the participants’ diets and their medical outcomes. One of the conclusions was that those who followed regular, very-low-carbohydrate diets ran the highest risk of dying from diseases ranging from stroke and heart disease, to cancer.

Even more telling was the fact that low-carb dieters who were not obese were more than twice as likely to die, than those who were obese. In other words, low-carb diets were much safer for people who needed to lose weight. They were more dangerous for those who weren’t obese. (18) That argues strongly for limited use of the keto diet.

A somewhat-similar study had a similar outcome. This one followed more than 15,000 Americans for 25 years. It found that the highest death rates occurred among those following low-carb or high-carb diets. Those who ate moderate amounts of carbohydrates didn’t die as often. Just as importantly, death rates among the low-carb dieters decreased when the carbs were replaced with plant-based foods. But deaths increased when carbs were replaced by animal fat and protein – the same prescription followed by keto dieters. (19)

Some keto advocates point to research claiming there are positive long-term effects to ketogenic eating. However, the studies they cite usually define “long-term” as periods of six months or so. (8) To date, there has been no major research supporting the use of keto for longer periods, or contradicting the two studies summarized earlier in this section.

Bottom line: there’s no firm proof either way, but it’s likely that the risk of a keto diet increases over time, particularly among those who are not obese and don’t need to lose weight.

Should You Be Scared of Starting a Keto Diet?

Probably not. You shouldn’t be scared of a short-term keto diet unless you have one of the medical risk factors we’ve mentioned – or unless you’re scared of putting aside potatoes, cake and fast food and replacing them with avocados, leafy green vegetables, dairy, protein and more olive oil and coconut oil.

Unlike paleo, vegan and Mediterranean diets, keto has been used as a medical treatment for decades; it’s definitely not just a “fad diet.” And the many benefits of a ketogenic diet plan have been well established and documented.

After you’ve entered the state of ketosis, low-carb/high-fat dieting should lead to improved cholesterol levels and lower blood pressure, as well as lower blood sugar and triglyceride levels. Those are all good indicators of future heart health. (20) Keto may even lower the risk of Parkinson’s and Alzheimer’s disease. (21) It will probably reduce your appetite, too.

Then there’s the benefit most keto dieters are most interested in: weight loss. Keto may not be the best diet to follow for a lifetime – but there’s no doubt that most people who follow keto guidelines for a few months will lose substantial amounts of weight. (22) 

(1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874681/

(2) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361831/

(3) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706352/

(4) https://pubmed.ncbi.nlm.nih.gov/15148063/

(5) https://pubmed.ncbi.nlm.nih.gov/15533250/

(6) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410243/

(7) https://pubmed.ncbi.nlm.nih.gov/30877806/

(8) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/

(9) https://www.ncbi.nlm.nih.gov/books/NBK499830/

(10) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905334/

(11) https://pubmed.ncbi.nlm.nih.gov/17621514/

(12) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425126/

(13) https://www.virtahealth.com/faq/ketogenic-diet-gout

(14) https://pubmed.ncbi.nlm.nih.gov/25649120/

(15) https://pubmed.ncbi.nlm.nih.gov/28076316/

(16) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566854/

(17) https://www.ncbi.nlm.nih.gov/books/NBK499830/

(18) https://pubmed.ncbi.nlm.nih.gov/31004146/

(19) https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(18)30135-X/fulltext

(20) https://pubmed.ncbi.nlm.nih.gov/19439458/

(21) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367001/

(22) https://pubmed.ncbi.nlm.nih.gov/12761365/